The 2025 HIPAA Security Rule update is here, marking the most significant change in over a decade. For healthcare providers, insurers, and business associates, the era of ambiguous SaaS-related controls that were open to interpretation has come to an end. The new HIPAA SaaS security mandates establish specific, enforceable requirements that directly impact how organizations govern and secure SaaS applications. This guide outlines the changes, their significance, and how SaaS security and compliance teams can stay ahead.